Signature Cord Prime™ Receives Investigational New Drug (IND) Approval from FDA for Phase 1 Study in Patients with Symptomatic Osteoarthritis of the Knee

Dallas, Texas., Feb. 16, 2021 /PRNewswire/-– Signature Biologics, LLC., a regenerative medicine company focused on the development, manufacture, and commercialization of cellular and tissue based products (HCT/P’s) for unmet human medical needs, today announced that the U.S. Food and Drug Administration (FDA) has approved an IND Application to proceed with the study of Signature Cord [...]

Signature Cord Prime™ Receives Investigational New Drug (IND) Approval from FDA for Phase 1 Study in Patients with Symptomatic Osteoarthritis of the Knee2021-03-09T16:03:52-06:00

Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels

Neil H. Riordan, Maria Luisa Hincapié, Isabela Morales, Giselle Fernandez, Nicole Allen, Cindy Leu, Marialaura Madrigal, Jorge Paz Rodriguez, Nelson Navarro First published: 11 June 2019 https://doi.org/10.1002/sctm.19-0010 Data Availability Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Abstract Individuals with autism spectrum disorder (ASD) [...]

Allogeneic Human Umbilical Cord Mesenchymal Stem Cells for the Treatment of Autism Spectrum Disorder in Children: Safety Profile and Effect on Cytokine Levels2021-02-25T10:03:59-06:00

The Effect of Umbilical Cord-derived Mesenchymal Stem Cell Transplantation in a Patient with Cerebral Palsy: A Case Report.

Okur SÇ1, Erdoğan S2, Demir CS3, Günel G3, Karaöz E2,3,4. Author Information: 1 Department of Physical Therapy and Rehab, Health Science University, Bakirköy Dr Sadi Konuk Training and Research Hospital, İstanbul, Turkey. 2 Department of Histology and Embryology, İstinye University, Faculty of Medicine, İstanbul, Turkey. 3 Center for Stem Cell and Tissue Engineering Research and Practice, İstinye University, İstanbul, [...]

The Effect of Umbilical Cord-derived Mesenchymal Stem Cell Transplantation in a Patient with Cerebral Palsy: A Case Report.2021-02-25T10:41:04-06:00

Spinal cord injury patients receiving BMMSC show improvements compared to control group

This 2013 study features a treatment group (who received bone marrow mesenchymal stem cells)  and a control group (who did not receive cells). 20 patients were in the treatment group and 20 in the control group, for a total of 40 patients with spinal cord injuries. The MSCs were harvested from the bone marrow of the [...]

Spinal cord injury patients receiving BMMSC show improvements compared to control group2021-02-25T12:29:22-06:00

Early study (2008) of bone marrow stem cells for spinal cord injury

Research on the treatment of spinal cord injury with cells from bone marrow aspirate was already ongoing more than a decade ago. This 2008 study followed 8 patients for for 2 years after receiving an average of 90 million CD34 cells directly to the spinal cord with no serious adverse events. The patients reported improvements [...]

Early study (2008) of bone marrow stem cells for spinal cord injury2021-02-25T12:40:10-06:00

Early treatment with BMMSC for spinal cord injury results in long-term benefits

The earlier, the better: in spinal cord injuries, treatment with mesenchymal stem cells may make a difference if applied soon after trauma. In this 2015 Polish case report, a 15 year old girl was treated with bone marrow MSC just 21 days after injury. She was paraplegic at the start of treatment (able to move [...]

Early treatment with BMMSC for spinal cord injury results in long-term benefits2021-02-25T13:26:50-06:00

Repeated doses of bone marrow MSCs bring nerve pain relief in spinal cord injury patients

Neuropathic pain, also known as nerve pain or neuralgia, occurs when there is damage to the nerves; it is one of the major consequences of spinal cord injury. In this study based in Spain, 10 patients received a dose of 100 million bone marrow MSCs, repeated at 4 months and 7 months. No adverse events [...]

Repeated doses of bone marrow MSCs bring nerve pain relief in spinal cord injury patients2021-02-25T13:42:41-06:00

MSC reverses opioid tolerance and opioid-induced hyperalgesia in rodents

Opioids are commonly prescribed to millions of patients for chronic pain. While they bring pain relief, they are associated with opioid tolerance (OT) - the body grows used to opioid medication and requires higher doses to manage pain adequately. Another condition associated with opioid use is opioid-induced hyperalgesia (OIH), where the patient grows even more [...]

MSC reverses opioid tolerance and opioid-induced hyperalgesia in rodents2021-02-25T15:43:35-06:00

Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy

Nina Mikirova, Neil Riordan, Joseph Casciari Med Sci Monit 2016; 22:14-25 DOI: 10.12659/MSM.895368 BACKGROUND: Cytokines play an important role in tumor angiogenesis and inflammation. There is evidence in the literature that high doses of ascorbate can reduce inflammatory cytokine levels in cancer patients. The objective of this study was to investigate the effect of treatment [...]

Modulation of Cytokines in Cancer Patients by Intravenous Ascorbate Therapy2021-03-01T12:46:43-06:00

Why Stem Cells Work: Clinical Trials for Spinal Cord Injury, Multiple Sclerosis, Rheumatoid Arthritis, and Duchenne’s Muscular Dystrophy

Dr. Riordan discusses: How our lab selects uses specialized screening techniques to select only the stem cells that we know will be the most useful for our patients. Only about 1 in 100 cords pass this screening process. How umbilical cord mesenchymal stem cells (MSC) control inflammation, modulate the immune system [...]

Why Stem Cells Work: Clinical Trials for Spinal Cord Injury, Multiple Sclerosis, Rheumatoid Arthritis, and Duchenne’s Muscular Dystrophy2021-03-01T13:32:02-06:00

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