Neuropathic pain, also known as nerve pain or neuralgia, occurs when there is damage to the nerves; it is one of the major consequences of spinal cord injury. In this study based in Spain, 10 patients received a dose of 100 million bone marrow MSCs, repeated at 4 months and 7 months. No adverse events were reported during the 10-month follow-up period. 9 out of 10 of patients reported relief in neuropathic pain. Their mean pain scores significantly decreased from 5.50 to 1.50, as measured by standard pain scales. This shows that MSC therapy (particularly in repeated doses) is a safe and potentially beneficial treatment option for spinal cord injury patients suffering from neuralgia.
Neurosci Lett. 2018 Mar 23;670:14-18. doi: 10.1016/j.neulet.2018.01.035. Epub 2018 Feb 2.
Intrathecal administration of autologous bone marrow stromal cells improves neuropathic pain in patients with spinal cord injury.
Vaquero J, Zurita M, Rico MA, Aguayo C, Fernández C, Gutiérrez R, Rodríguez-Boto G, Saab A, Hassan R, Ortega C.