Project Description

Regenerative Medicine

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Regenerative Medicine

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Regenerative Medicine at RMI

Riordan Treatment Protocols

Riordan Medical Institute’s protocols combine the latest scientific advances in bone marrow harvesting with three complimentary cellular technologies: Bone Marrow Aspirate Concentrate (BMAC), *umbilical cord tissue product, and *amniotic tissue product.

Non-surgical use of Riordan protocols may provide an alternative to surgery using simple, elegant solutions to difficult problems.

Possible effects of Riordan include:

  • Shorter healing times

  • Increased vascularization

  • Less pain for patients

  • Increased safety rate with harvesting method

  • Reduced inflammation

  • Decreased risk of infection

Regenerative Medicine at RMI

Riordan Treatment Protocols

Riordan Medical Institute’s protocols combine the latest scientific advances in bone marrow harvesting with three complimentary cellular technologies: Bone Marrow Aspirate Concentrate (BMAC), *umbilical cord tissue product, and *amniotic tissue product.

Non-surgical use of Riordan protocols may provide an alternative to surgery using simple, elegant solutions to difficult problems.

Possible effects of Riordan include:

  • Shorter healing times

  • Increased vascularization

  • Less pain for patients

  • Increased safety rate with harvesting method

  • Reduced inflammation

  • Decreased risk of infection

We Feature

  • Board-certified interventional pain management specialist
  • Over 30 years collective experience in regenerative medicine
  • Amniotic and umbilical cord tissue products developed by applied stem cell research expert, Neil H. Riordan, PA, PhD
  • Bone Marrow Aspirate concentration (BMAC) with tabletop centrifuge.
  • Platelet-Rich Plasma (PRP)
  • Efficient bone marrow harvesting using fluoroscopic guidance (C-Arm)
  • Precision injections with ultrasound and/or fluoroscopic guidance
  • All regenerative products are handled only by our full-time clinical staff members who have 7 to 14 years of regenerative medicine experience each. Your tissue will never be handled by a third-party contractor.

Signature Cord

Signature Cord is an umbilical cord tissue product developed by Dr. Riordan that originates from the same tissue that his lab in Panama uses to manufacture its purified, expanded mesenchymal stem cell product used by Stem Cell Institute to treat a variety of chronic conditions.

The difference is that the cord tissue product used in the US is derived from dissociated umbilical cord tissue following minimally-manipulated procedures that differ from the manufacturing processes employed in Panama.

This product is a natural source of growth factors and hyaluronic acid. Most importantly, its processing in the US maintains the source material integrity required for tissue repair.

Visit Signature Biologics: www.signaturebiologics.com

Signature Matrix

Signature Matrix is a pliable allograft (transplant) derived from human placental amnion, which functions as a biologic structural matrix to facilitate and enhance tissue healing and repair.

Amniotic tissue has been used since 1910 in the US and is now FDA-exempt for treating wounds and other conditions. It was first used for treating eye problems, primarily corneas and is still widely used in ophthalmology today. Once the baby is born, the placenta along with the amniotic sack and what’s left of the umbilical cord come out. It’s called afterbirth and is usually discarded.

Amniotic tissue is procured from contracted hospitals after normal, healthy births. Once it has been fully tested for infectious diseases, sterility and a few other things, the tissue is processed.

Using proprietary technology, the tissue is separated into very small particles that are cryo-preserved in a special way that keeps the integrity of the tissue the same as it was when it came out after the healthy birth of the child.

Visit Signature Biologics: www.signaturebiologics.com

Bone Marrow Aspirate Concentrate (BMAC)

BMAC comes from your own bone marrow and contains a wealth of cells which can aid the body in its own recovery.

BMAC can be highly effective for bone, muscle, tendon, ligament and cartilage injuries. Bone marrow is an excellent source for the cells and growth factors that are responsible for the healing and tissue regeneration process.

At RMI, we employ a vertical axis centrifuge specifically calibrated to produce bone marrow concentrate (BMAC) in order to maximize nucleated cell yield. Studies have shown that this process can produce a nucleated cell yield percentage over twice that of Arteriocyte Magellan centrifuges and about 20% more than other competing technologies.

The Science Behind BMAC

BMAC contains mesenchymal stem cells (MSC), CD34+ stem cells, growth factors and (mesenchymal) trophic factors (MTF).

  • MSCs reduce inflammation, regulate the immune system and secrete factors that stimulate tissue regeneration. The better the blood supply, the faster surgical wounds and orthopedic injuries will heal and the more conducive the environment will be for MSC to flourish.
  • CD34+ stem cells are blood-forming cells. They induce blood vessels to grow (angiogenesis). CD34+ stem cells are the most angiogenic cells in the body.
  • Growth factors in BMAC are capable of stimulating cellular growth, proliferation, healing and differentiation (changing into another type of cell such as a blood vessel cell).
  • Mesenchymal Trophic Factors (MTF) are secreted by MSC. Most of the benefits commonly attributed to MSC (see above), are actually due to the trophic factors they secrete.

Harvesting Bone Marrow

The entire process takes about 10-15 minutes. Since each patient is under conscious sedation, they feel no pain during the procedure.

The doctor uses fluoroscopic imaging (C-Arm) to ensure that the needle accesses a thick area of bone marrow in order to ensure the highest quality bone marrow sample containing the greatest possible number of stem cells. Normally we draw 60 – 120 cc (2 – 4 ounces) of bone marrow.

Afterwards, most patients don’t even realize where the bone marrow was taken out until they discover the entry point. Some patients might experience a small bruise but it’s not uncommon to have no bruising at all.

Is Bone Marrow Safe?

Because BMAC is autologous, meaning it comes from the patient’s own body, the likelihood of any adverse side effects due to the BMAC itself is exceedingly low. To-date, there have never been any reports of adverse side effects.

Bone Marrow Aspirate Concentrate (BMAC)

BMAC comes from your own bone marrow and contains a wealth of cells which can aid the body in its own recovery.

BMAC can be highly effective for bone, muscle, tendon, ligament and cartilage injuries. Bone marrow is an excellent source for the cells and growth factors that are responsible for the healing and tissue regeneration process.

At RMI, we employ a vertical axis centrifuge specifically calibrated to produce bone marrow concentrate (BMAC) in order to maximize nucleated cell yield. Studies have shown that this process can produce a nucleated cell yield percentage over twice that of Arteriocyte Magellan centrifuges and about 20% more than other competing technologies.

The Science Behind BMAC

BMAC contains mesenchymal stem cells (MSC), CD34+ stem cells, growth factors and (mesenchymal) trophic factors (MTF).

  • MSCs reduce inflammation, regulate the immune system and secrete factors that stimulate tissue regeneration. The better the blood supply, the faster surgical wounds and orthopedic injuries will heal and the more conducive the environment will be for MSC to flourish.
  • CD34+ stem cells are blood-forming cells. They induce blood vessels to grow (angiogenesis). CD34+ stem cells are the most angiogenic cells in the body.
  • Growth factors in BMAC are capable of stimulating cellular growth, proliferation, healing and differentiation (changing into another type of cell such as a blood vessel cell).
  • Mesenchymal Trophic Factors (MTF) are secreted by MSC. Most of the benefits commonly attributed to MSC (see above), are actually due to the trophic factors they secrete.

Harvesting Bone Marrow

The entire process takes about 10-15 minutes. Since each patient is under conscious sedation, they feel no pain during the procedure.

The doctor uses fluoroscopic imaging (C-Arm) to ensure that the needle accesses a thick area of bone marrow in order to ensure the highest quality bone marrow sample containing the greatest possible number of stem cells. Normally we draw 60 – 120 cc (2 – 4 ounces) of bone marrow.

Afterwards, most patients don’t even realize where the bone marrow was taken out until they discover the entry point. Some patients might experience a small bruise but it’s not uncommon to have no bruising at all.

Is Bone Marrow Safe?

Because BMAC is autologous, meaning it comes from the patient’s own body, the likelihood of any adverse side effects due to the BMAC itself is exceedingly low. To-date, there have never been any reports of adverse side effects.

How can some amniotic tissue products augment a patient’s bone marrow stem cells?

Image of bone marrow stem cells with and without amnion

The cells on the left, which were cultured with amniotic tissue product, have the morphology of young, healthy MSCs. No flattening, a red color of mitochondria, and they’re spread throughout the whole cell body. On the right, you’ll notice in cells that were not cultured with amniotic tissue product, the cells are flat and fibroblastic looking. They are becoming senescent, the last step before they stop producing growth signals and can do nothing but basically form scar tissue.

How can some amniotic tissue products augment a patient’s bone marrow stem cells?

Image of bone marrow stem cells with and without amnion

The cells on the left, which were cultured with amniotic tissue product, have the morphology of young, healthy MSCs. No flattening, a red color of mitochondria, and they’re spread throughout the whole cell body. On the right, you’ll notice in cells that were not cultured with amniotic tissue product, the cells are flat and fibroblastic looking. They are becoming senescent, the last step before they stop producing growth signals and can do nothing but basically form scar tissue.

Platelet-Rich Plasma (PRP)

Platelet-rich plasma (PRP) is extracted from the patient’s own blood using venipuncture, like when a patient is giving blood for labs. Using our cutting-edge in-house lab, we focus on preparing PRP tailored to each patient’s specific needs. We can prepare the PRP to be leukocyte rich, leukocyte poor, or to specific concentrations (up to >20x of whole blood platelet count). We are able to achieve these concentrations using our NSF/ANSI 49 hood and using our Revolve Echo lab-grade microscope to perform cell and platelet counts. Additionally, we (collectively through Dr Riordan’s lab and other business units) work with a few PRP kit vendors to offer more affordable options for patients rather than manually prepared PRP.

Platelet-Rich Plasma (PRP)

Platelet-rich plasma (PRP) is extracted from the patient’s own blood using venipuncture, like when a patient is giving blood for labs. Using our cutting-edge in-house lab, we focus on preparing PRP tailored to each patient’s specific needs. We can prepare the PRP to be leukocyte rich, leukocyte poor, or to specific concentrations (up to >20x of whole blood platelet count). We are able to achieve these concentrations using our NSF/ANSI 49 hood and using our Revolve Echo lab-grade microscope to perform cell and platelet counts. Additionally, we (collectively through Dr Riordan’s lab and other business units) work with a few PRP kit vendors to offer more affordable options for patients rather than manually prepared PRP.

View/download the entire chapter about stem cell therapy for orthopedic conditions from Dr. Riordan’s book

Image of Dr Riordan's Book

For more detailed information about our treatments, we welcome you to read/download the entire chapter on stem cell therapy for orthopedic conditions from Dr. Riordan’s new book, Stem Cell Therapy: A Rising Tide – How Stem Cells are Disrupting Medicine and Transforming Lives. CLICK HERE (FREE PDF)

“Neil takes readers on a riveting journey through the past, present and future of stem cell therapy. His well-researched, educational and entertaining book could change your life. I highly recommend it.” – Tony Robbins, NY Times #1 Bestselling Author

“100 years old will soon become the new 60. Stem cells are a key therapeutic to enable this future. Dr. Riordan’s book is your guide to why this is true and how you will benefit. A must read for anyone who cares about extending their healthy lifespan.” – Peter H. Diamandis, MD; Founder, XPRIZE & Singularity University; Co-Founder, Human Longevity, Inc.; Author of NY Times Best Sellers Abundance and Bold

View/download the entire chapter about stem cell therapy for orthopedic conditions from Dr. Riordan’s book

Image of Dr Riordan's Book

For more detailed information about our treatments, we welcome you to read/download the entire chapter on stem cell therapy for orthopedic conditions from Dr. Riordan’s new book, Stem Cell Therapy: A Rising Tide – How Stem Cells are Disrupting Medicine and Transforming Lives. CLICK HERE (FREE PDF)

“Neil takes readers on a riveting journey through the past, present and future of stem cell therapy. His well-researched, educational and entertaining book could change your life. I highly recommend it.” – Tony Robbins, NY Times #1 Bestselling Author

“100 years old will soon become the new 60. Stem cells are a key therapeutic to enable this future. Dr. Riordan’s book is your guide to why this is true and how you will benefit. A must read for anyone who cares about extending their healthy lifespan.” – Peter H. Diamandis, MD; Founder, XPRIZE & Singularity University; Co-Founder, Human Longevity, Inc.; Author of NY Times Best Sellers Abundance and Bold

Are you a candidate? Contact us today to find out.

In-person and online evaluations are available.

APPLY

Are you a candidate? Contact us today to find out.

In-person and online evaluations are available.

APPLY