A study published in the Jul-Dec 2014 edition of the Journal of Natural Science, Biology and Medicine entitled “Bone marrow injection: A novel treatment for tennis elbow“ concluded that a single injection of bone marrow aspirate concentrate (BMAC) into the elbow led to significant improvement of patients suffering from tennis elbow.
The study followed 30 patients for 12 weeks and concluded that treatment of tennis elbow patients with single injection of BMA showed a significant improvement in short to medium term follow-up.
Perhaps more importantly, it concluded that, “In the future, such growth factors and/or stem cells based injection therapy can be developed as an alternative conservative treatment for patients of tennis elbow, especially who have failed non-operative treatment before surgical intervention is taken.”
Fast forward to the present where at RMI, we are augmenting BMAC with *AlphaGEMS, a proprietary, pliable tissue allograft (transplant) derived from human placental amnion, which functions as a biologic structural matrix to facilitate and enhance tissue healing and repair. AlphaGEMS contains 108 different growth factors including WNT-4 and prostaglandin.
Prostaglandin inhibits inflammation, which occurs after injury and marks the beginning of the healing process. The faster we can tame this inflammation, the sooner the body can move on to the next phase of healing, regeneration. It’s important to note that AlphaGEMS has more than 60 times the amount of prostaglandin compared to other products.
WNT4 is arguably the single most important molecule required for wound healing. AlphaGEMS has more than 10 times the amount of WNT4 as competing products.
For more information about BMAC and AlphaGEMS at the Riordan-McKenna Institute Click Here.
If you are suffering from tennis elbow and would like to be evaluated for treatment, please start by completing our online medical history. Once we receive it, our staff will contact you to answer general questions and guide you through the rest of the application process, which usually includes a in-office evaluation with Dr. McKenna for local patients or a free telephone consultation for those who live further away.
About Tennis Elbow
Tennis elbow is an inflammation of the tendons that join the forearm muscles on the outside of the elbow. The forearm muscles and tendons become damaged from overuse — repeating the same motions again and again. This leads to pain and tenderness on the outside of the elbow. More on Tennis Elbow from AAOS.
About: Bone marrow injection: A novel treatment for tennis elbow
The objective of this prospective study was assessment of efficacy of bone marrow aspirate (BMA) (containing plasma rich in growth factors and mesenchymal stem cells) injection in treatment of tennis elbow.
Materials and Methods:
A total of 30 adult patients of previously untreated tennis elbow were administered single injection of BMA. This concentrate was made by centrifugation of iliac BMA at 2000 rpm for 20-30 min and only upper layer containing platelet rich plasma and mononuclear cells was injected. Assessment was performed at baseline, 2 weeks, 6 weeks and 12 weeks using Patient-rated Tennis Elbow Evaluation (PRTEE) score.
Baseline pre-injection mean PRTEE score was 72.8 ± 6.97 which decreased to a mean PRTEE score of 40.93 ± 5.94 after 2 weeks of injection which was highly significant (P < 0.0001). The mean PRTEE score at 6 week and 12 week follow-up was 24.46 ± 4.58 and 14.86 ± 3.48 respectively showing a highly significant decrease from baseline scores (P < 0.0001). Conclusion:
Treatment of tennis elbow patients with single injection of BMA showed a significant improvement in short to medium term follow-up. In future, such growth factors and/or stem cells based injection therapy can be developed as an alternative conservative treatment for patients of tennis elbow, especially who have failed non-operative treatment before surgical intervention is taken.
*Tissue used for AlphaGEMS is donated after normal, healthy births. Once it has been fully tested for infectious diseases, sterility and a few other things, the tissue is processed by using proprietary methods developed by Neil Riordan, PhD.