Knee Treatment at RMI

If you suffer from chronic knee pain due to arthritis or an old injury, or you’ve recently injured your knee meniscus, cartilage or ligaments (ACL, MCL) you may benefit from non-surgical stem cell injections or stem cell-enhanced surgery.

Can Stem Cells Regenerate Cartilage?

X-Rays show evidence of cartilage regeneration in the knee
MRI Scan shows cartilage regeneration in the knee.

Terry Hamrick Bone on Bone Quote 2

About the Knee

The knee is the joint where the bones of the upper leg meet the bones of the lower leg, allowing hinge-like movement while providing stability and strength to support the weight of the body. Flexibility, strength, and stability are needed for standing and for motions like walking, running, crouching, jumping, and turning.

Several kinds of supporting and moving parts, including bones, cartilage, muscles, ligaments, and tendons, help the knees do their job. Each of these structures is subject to disease and injury.

When a knee problem affects your ability to do things, it can have a big impact on your life. Knee problems can interfere with many things, from participation in sports to simply getting up from a chair and walking.

Stemnexa combines a patient’s own bone marrow stem cells with amniotic membrane tissue to treat bone, muscle, tendon, ligament and cartilage damage in the knee. The amniotic we use is composed of collagens and other structural proteins, which provide a biologic matrix that supports angiogenesis, tissue growth and new collagen production during tissue regeneration and repair.

RMI Stem Cell Therapy Patients in Their Own Words


Stem Cell Therapy for Knee Pain and Injuries

Teresa Hamrick, RN


Stem Cell Therapy for Anterior Cruciate Ligament (ACL) Repair

Jennifer Ziegler

Will a stem cell injection fix my knee?

This is a question that everyone who is looking at stem cell therapy to avoid knee surgery asks. The answer is, “It depends.”

Stem cell injections are not a panacea that will fix every knee injury regardless of type and severity.

Cartilage Fragments in Knee For example, a patient might have loose bodies like cartilage or bone fragments inside their knee joint, which can cause painful inflammation, degeneration of the joint and “catching” of the knee. These loose bodies must be surgically removed. Stem cell injections are not going to make them go away. However, stem cells and other biologics like amniotic tissue product can be used to promote faster healing after loose bodies are removed with minimally invasive surgery.

As one can see in the picture to the left, these loose bodies can be quite large.

Treating this kind of condition with stem cells alone might alleviate some of the inflammation temporarily but the since underlying problem hasn’t been addressed, the inflammation will return, the catching isn’t going to stop and the degeneration will continue. Cartilage Fragments Knee Scope

A view inside a patient’s knee makes it easy to see how fragments inside the joint can make it painful and difficult to bend. Constant grinding causes discomfort and gradual degeneration of the knee joint over time.

The bottom line is that injecting stem cells without removing large loose bodies is a waste of stem cells, time and money. One should rely on the expertise of a board-certified orthopedic surgeon with years of experience in regenerative medicine to determine when BMAC and amniotic tissue product injections are the right choice and when when minimally invasive surgery augmented with stem cells and amniotic tissue product is a better option.

What makes stem cell therapy at RMI different?



At RMI, we augment BMAC with a proprietary, pliable tissue allograft (transplant) derived from human placental amnion, which functions as a biologic structural matrix to facilitate and enhance tissue healing and repair. It contains 108 different growth factors including more than 10 times the amount of WNT-4 and and more than 60 times the amount of prostaglandin as competing products.

Prostaglandin inhibits inflammation, which occurs after injury and marks the beginning of the healing process. The faster we can tame this inflammation, the sooner the body can move on to the next phase of healing, regeneration.

WNT4 is arguably the single most important molecule required for wound healing.

For more information about BMAC and amniotic tissue products at the Riordan-McKenna Institute Click Here.


A New Standard of Care in ACL Reconstruction

Additional videos are highlighted in orange to the right

Additional videos are highlighted in orange below

Common knee conditions treated at Riordan-McKenna Institute (RMI):

Below are common knee conditions we treat at RMI. If your knee condition is not listed, please contact us to see if you are a candidate.


Amniotic tissue is donated after normal, healthy births. Once it has been fully tested for infectious diseases, sterility and a few other things, the tissue is processed by using proprietary methods developed by Neil Riordan, PhD.